There is strong evidence that exercise is wildly beneficial. There is even stronger evidence that most people hate to exercise. So if a pill could mimic the effects of working out, why wouldn’t we want to take it?

Recorded live in San Francisco. Guests include the keeper of a 10,000-year clock, the co-founder of Lyft, a pioneer in male birth control, a specialist in water security, and a psychology professor who is also a puppy. With co-host Angela Duckworth, fact-checker Mike Maughan, and the Freakonomics Radio Orchestra.