Scientific research & publishing are gruelling tasks that extend outside the scope of science itself. Centralised publications abound in archaic practices that span from submitting a paper to getting it peer-reviewed and finally published, process which may take even up to years. In addition, research requires funding from very early stages of pursuing an idea, all the way to its finality (i.e. clinical trial or real-life applications). In TradSci (traditional science), funding is usually obtained once progress has already been achieved or when a startup has been formed. DeSci (decentralised science) sets out to change this paradigm by funding early stage research via DAOs. When it comes to scientific publications, peer reviewing is also decentralised and incentivised, considerably speeding up the process. Moreover, contributions can be clearly retraced, avoiding false claims over IP, and the research itself becomes much more easily accessible and disseminated. We were joined by Vincent Weisser & Laurence Ion, stewards of Vita DAO, to discuss the advantages of DeSci in general, and the progress of longevity research in particular. Topics covered in this episode: Vincent’s background and his interest in longevityLaurence’s background and his interest in biotechThe purpose of DeSciWhich science branch is better suited for DeSciHow DeSci fixes contribution acknowledgement & incentive misalignmentFrom research idea to startup via DeSci funding$VITA token utilityAccelerating scientific publishing via DeSciHow IP is attributed in a DeSci settingProject review and governance in Vita DAOEpisode links: Vincent WeisserLaurence IonVita DAOMolecule DAOVita DAO projectsMoleculeBio DAO launchpadThe Longevity PrizeThe Longevity Decentralized ReviewThis episode is hosted by Friederike Ernst & Meher Roy. Show notes and listening options: epicenter.tv/488

With the upcoming launch of Polygon's zkEVM mainnet, L2s are undoubtedly a huge narrative that is unfolding in 2023. It is time to take a step back and recognise the incredible amount of effort that has gone into researching and building L2 scaling solutions in general and zk rollups in particular. Tech-wise, we barely scratched the surface of general purpose processors that can handle zk circuits, so there is still tremendous room to grow. As layer 2s become more efficient, so will the applications that are dependent on blockchain throughput. We were joined by Jordi Baylina (tech lead) & David Schwartz (CTO) from Polygon's zkEVM, to discuss the different milestones & challenges they had to overcome in designing a zk rollup, from circuits to mainnet. Topics covered in this episode: Jordi’s & David’s backgroundsThe idea behind Hermez NetworkzkEVM scaling & validity proofsHow different ZK rollup models functionWhat challenges zkEVM encountered during developmentEvolutionary pathways in the realm of ZKPsAuditing zkEVMTrusted setup requirement for zkEVMEpisode links: Jordi Baylina on TwitterDavid Schwartz on TwitterPolygon zkEVM on TwitterSponsors: Omni: Access all of Web3 in one easy-to-use wallet! Earn and manage assets at once with Omni's built-in staking, yield vaults, bridges, swaps and NFT support. https://omni.app/ -This episode is hosted by Friederike Ernst & Meher Roy. Show notes and listening options: epicenter.tv/486