with Jorge Conde (@JorgeCondeBio), Julie Yoo (@julesyoo), and Hanne Tidnam (@omnivorousread) Building a software company in healthcare is hard -- and comes along with unique challenges no other entrepreneurs face. In this conversation, a16z bio general partner -- and previous founder of genomics company Knome -- Jorge Conde; and a16z bio partner and former founder Julie Yoo (of patient provider matching system, Kyruus) share their mistakes and hard earned lessons learned with a16z partner Hanne Tidnam. Why is this so damn hard? How should founders think about this space differently? What are the specific things that healthcare founders can do -- when, where, and why? You'll wish you only knew this when you started your own company!

In this episode of the a16z Podcast -- which originally aired as a video on YouTube -- general partner Alex Rampell (and former fintech entrepreneur as the CEO and co-founder of TrialPay) talks with operating partner Frank Chen about the quickly changing fintech landscape and, even more importantly, why the landscape is changing now. Should the incumbents be nervous? About what, exactly? And most importantly, what should big companies do about all of this change? But the conversation from both sides of the table begins from the perspective of the hungry and fast fintech startup sharing lessons learned, and then moves to more concrete advice for the execs in the hot seat at established companies. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investor or prospective investor, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund which should be read in their entirety.) Past performance is not indicative of future results. Any charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Please see https://a16z.com/disclosures for additional important information.