Welcome to the second episode of Bio Eats World, a brand new podcast all about how biology is technology. Bio is breaking out of the lab and clinic and into our daily lives -- on the verge of revolutionizing our world in ways we are only just beginning to imagine. Many diseases are caused by proteins that have gone haywire in some fashion. There could be too much of the protein, it could be mutated, or it could be present in the wrong place or time. So how do you get rid of these problematic proteins? In this episode of Journal Club (now on Bio Eats World), Stanford professor Carolyn Bertozzi and host Lauren Richardson discuss the article “Lysosome-targeting chimaeras for degradation of extracellular proteins” by Steven Banik, Kayvon Pedram, Simon Wisnovsky, Green Ahn, Nicholas Riley, and Carolyn Bertozzi, published in Nature (2020). Dr. Bertozzi and  her lab developed a class of drugs — or modality — that tosses the disease-related proteins into the cellular trash can. While there are other drugs that work through targeted protein degradation, these drugs called LYTACs are able to attack a set of critical proteins, some of which have never been touched by any kind of drug before. The conversation covers how they engineered these new drugs, their benefits, and how they can be further optimized and specialized in the future.

With the U.S. tech partnership for TikTok being finalized, what happens if source code is excluded (and more specifically, the For You Page algorithm), given China’s revised export controls? But more broadly -- well beyond the specifics and politics of this deal -- what does the success of TikTok tell us about “creativity network effects”, where every additional creator makes the rest of the community more creative? How did "seeing like an algorithm" and the new age of algorithm-friendly product design enable the short video-sharing platform to grab massive marketshare in cultures and markets never experienced firsthand by the engineers and designers in China, beating out other dominant players and apps in the United States? In this episode of 16 Minutes -- our show where we discuss what's in the news, tease apart what's hype/ what's real, and  where we are on the long arc of innovation  with specific tech trends with top experts -- Eugene Wei (former head of product at Hulu, Flipboard, and video at Oculus) joins us. We also touch on the future of entertainment, education, and the power and future of video. full transcript here: https://a16z.com/2020/09/18/16mins-tiktok-seeing-like-an-algorithm-friendly-design-creativity-network-effects-video/ --- This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.