Healthcare is a $4 trillion industry, making up nearly a fifth of the U.S. economy—but despite having some of the best doctors and advanced technology, the system often delivers poor outcomes at skyrocketing costs. Why is this the case, and what will it take to fix it? In this episode, a16z cofounder Marc Andreessen and General Partners Vijay Pande and Julie Yoo tackle some of the biggest questions shaping the future of healthcare: Is the solution to our healthcare crisis a policy, technology, or competition problem?Will AI and technology transform the industry, or are regulatory and structural barriers too entrenched?Who will crack the code—healthcare incumbents, tech giants, or AI-native startups?From chronic care to cost curves, from disruptive technologies to shifting patient agency, this conversation offers an unfiltered look at what’s broken in the healthcare system and how it might finally change. Resources:  Find Marc on X: https://x.com/pmarca Find Vijay on X: https://x.com/vijaypande Find Julie on X: https://x.com/julesyoo The Biggest Company in the World Why Will Healthcare be the Industry that Benefits Most from AI? Grand Challenges in Healthcare AI with Vijay Pande and Julie Yoo Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @sambroner @meigga @darenmatsuoka @jneu_net @chrislyons and @rhhackett @smc90 Welcome to our special end-of-year episodes -- which also look ahead to 2025 --  covering our annual Big Ideas lists, where various a16z crypto team members share what they are personally excited about. (You can see the firmwide list, also including all the trends of the crypto team,  here.) This episode is part 1 of 2 -- but you don't have to listen to them in any particular order -- covering the trends and themes of: stablecoins, payments, and where the early adopters will come from;app store distribution, curation, and discovery;where the next crypto users will come from, turning passive holders into active users;how builders improve, and better choose, infrastructure; andsimplifying user experience. Covering each of these -- and coming from the investing, go-to-market, data science, research, and media teams are:  Sam Broner, Maggie Hsu, Daren Matsuoka, Joachim Neu, and Chris Lyons; in conversation with hosts Sonal Chokshi and Robert Hackett. (Stay tuned until the end for some of our meta-commentary.)  These are just 5 of the 14 trends we shared; you can check out the full list at a16zcrypto.com/bigideas. Also be sure to check out part 2, which covers all the trends at the intersection of crypto and AI.  As a reminder, none of the content is investment, business, legal, or tax advice; please see a16z.com/disclosures for more important information -- including a link to a list of our investments.