What’s the first thing you do when you wake up in the morning and the last thing you do before bed? If you’re a modern knowledge worker, your answer is probably “check my email.” Makes sense. Your inbox is a busy place, which is why you peek at it, on average, every six minutes: constant vigilance is the only way to keep up. But all that checking comes at a cost. Communication overload undermines your productivity, erodes your focus, zaps your energy, and makes you miserable. Luckily, Cal Newport, the Georgetown professor and productivity whiz who came up with “deep work” and “digital minimalism,” has a plan for a post-email future, one where you can concentrate on work that really matters. And in this episode, he shares practical strategies that you can start using now to free yourself from the tyranny of the inbox.

Almost a decade ago, the biochemist Jennifer Doudna and her team at Berkeley figured out how to rewrite our genetic code using a system called CRISPR. Thanks to this miraculous discovery, we now have the power to hunt down cancer cells, deflect oncoming viruses, and cure genetic diseases. But CRISPR has a dark side, morally speaking. In a world where we’ll soon have the power to endow our kids with superior strength and intelligence, how far is too far? Doudna’s groundbreaking discovery and the moral dilemmas that followed are the subject of a new book by best-selling biographer Walter Isaacson. In this expansive conversation, he tells Rufus why the CRISPR era will be far more consequential than the digital revolution. Plus, they discuss the mechanics of creativity, the delicate balance between competition and collaboration, and the personality traits that Isaacson’s subjects — Doudna, da Vinci, Ben Franklin, Einstein, and Steve Jobs — all have in common.